Prophylactic Antibiotics for Prevention of Infective Endocarditis or Bacteremia in Pediatric Patients With Congenital Heart Disease Undergoing Dental Procedures: Systematic Review.

ABSTRACT:

Aim

To assess the effectiveness of prophylactic antibiotics in preventing infective endocarditis (IE) after dental procedures in pediatric patients with congenital heart disease.

Methods

Six electronic databases and grey literature were searched for randomized controlled trials (RCTs), case-control studies, and cohort studies in pediatric patients who received antibiotic prophylaxis (AP) before any dental procedure compared to pediatric patients undergoing the same procedures without AP to prevent IE and/or bacteremia. The Newcastle-Ottawa scale was used to evaluate the internal validity of the included studies. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the certainty of evidence.

Results

1774 studies were screene

SUBMITTER: Loper C 

PROVIDER: S-EPMC12637016 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature