Multilayered structure on titanium implants promotes diabetic osseointegration through synergetic regulation of oxidative balance and immune homeostasis in microenvironment.

ABSTRACT: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and chronic inflammation, which is considered a relative contraindication for implantation in clinical practice. In the pathological microenvironment of DM, the endless vicious cycle of oxidative stress-immune disorder-chronic inflammation severely inhibits new bone formation, causing the stagnant healing and poor osseointegration. Herein, we design a multilayered structure composing of 18β-glycyrrhetinic acid modified chitosan (CS-GA) and gelatin (Gel) embedded with trimanganese tetroxide nanozymes (Mn₃O₄) on the surface of titanium implant through layer-by-layer self-assembly technique (LBL), namely LBL-GA@Mn. In vitro biological tests show that under the action of Mn₃O

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12637064 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature