Biohybrid system EcN@PB for reshaping tumor immunosuppressive microenvironment to improve photothermal therapy induced antitumor immune response.

ABSTRACT: Photothermal therapy (PTT) is a promising tumor treatment with high selectivity, precise targeting, and low side effects. It induces photothermal ablation of tumors, and activates anti-tumor immune response by promoting immunogenic cell death (ICD) of tumor cells. Prussian Blue (PB) mediated PTT has made great progress, but high interstitial fluid pressure and solid stress in tumors significantly inhibited PB accumulation and diffusion, seriously affecting its PTT effect. Herein, we constructed a novel biohybrid system EcN@PB to enhance the PB-mediated photothermal immunotherapy. EcN@PB utilized the inherent tumor targeting ability of EcN to achieve precise delivery of PB to the tumor. On tumor-bearing mouse model, we demonstrated that EcN@PB selectively accumulated in tumors and achieved

SUBMITTER: Feng Q 

PROVIDER: S-EPMC12637071 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature