Identification of Donor-recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study.

ABSTRACT:

Background

Kidney marginality criteria consider the impact of donor characteristics on graft failure risk. To evaluate graft quality according to both the donor and recipient, we identified recipient characteristics that may modify the predictive capacity of a donor marginality score.

Methods

From the French DIVAT (Données Informatisées et VAlidées en Transplantation) cohort, we included 8299 patients who received a single deceased donor kidney graft between 2000 and 2022. From the learning sample (n = 5533), we constructed a Cox model with death or return to dialysis as the outcome. The model was both internally (n = 2766) and externally (n = 3178) validated. A recipient-relative marginality score was defined by screening the interactions between recipient characteristics a

SUBMITTER: Choisy C 

PROVIDER: S-EPMC12637153 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature