JMJD8 facilitates hepatic lipid deposition and metabolic dysfunction.

ABSTRACT: We previously identified Jumonji domain-containing 8 (JMJD8) as a regulator of lipid droplet (LD) hypertrophy in adipocytes through modulation of AMPK-dependent perilipin-2 (PLIN2) phosphorylation. Given PLIN2's established role in hepatic steatosis, we investigated whether JMJD8 also regulates lipid accumulation in the liver. Here, we report that JMJD8 expression is significantly elevated in the livers of mice fed either a high-fat diet (HFD) or the metabolic-associated fatty liver disease (MAFLD)-inducing Gubra Amylin NASH (GAN) diet. To define the metabolic role of JMJD8 in the liver, we generated liver-specific Jmjd8 knockout (Jmjd8^LKO) mice. Hepatic deletion of Jmjd8 reduced triglyceride (TG) accumulation under both dietary conditions, without affecting

SUBMITTER: You D 

PROVIDER: S-EPMC12637200 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature