Asprosin as a regulator of hepatic lipogenesis and its association with hepatic steatosis.

ABSTRACT: Asprosin is a recently discovered adipokine involved in the regulation of hepatic gluconeogenesis and appetite, but its role in hepatic lipid metabolism, a key aspect of metabolic dysfunction-associated steatotic liver disease (MASLD), is unknown. This study aimed to investigate whether asprosin could regulate hepatic lipid metabolism in vitro and in an animal model and to determine the potential association between circulating levels of asprosin and the severity of hepatic steatosis in humans. The effects of asprosin on the metabolic phenotype of mice with diet-induced obesity (DIO), as well as on de novo lipogenesis, β-oxidation, and mitochondrial function, were analyzed in both cultured primary hepatocytes and mice by assessing mRNA and protein levels of metabolic pathway components, al

SUBMITTER: Acevedo-Carabantes JA 

PROVIDER: S-EPMC12637223 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature