An operant social self-administration and choice model in mice.

ABSTRACT: Little is known about how social factors contribute to neurobiology or neuropsychiatric disorders. The use of mice allows one to probe the neurobiological bases of social interaction, offering the genetic diversity and versatility to identify cell types and neural circuits of social behavior. However, mice typically show lower social motivation compared with rats, leading to the question of whether mice should be used to model complex social behaviors displayed by humans. Studies on mouse social behavior often rely on measures such as time spent in contact with a social partner or preference for a social-paired context, but fail to assess volitional (subject-controlled) rewarding social interaction. Here, we describe a volitional social self-administration and choice model that is an exten

SUBMITTER: Ramsey LA 

PROVIDER: S-EPMC12637245 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature