Oxidation of hemoglobin to ferryl hemoglobin contributes to remodeling of the artery wall in abdominal aortic aneurysm.

ABSTRACT: Abdominal aortic aneurysm (AAA) with potentially fatal outcomes affects cardiovascular health via inflammation-related abnormalities. We revealed the presence of the oxidized hemoglobin (Hb), ferrylHb in the circulation in patients diagnosed with ruptured AAA. The aim of our study was to identify the source of oxidation of Hb in human hemorrhaged AAA and in an angiotensin II provoked AAA model in mice leading to generation of ferrylHb and to describe its fate in the pathophysiology. We demonstrate that two electron oxidations of Hb leading to the formation of ferrylHb with the characteristics of oxidation of βCys93, αCys104, and βCys112 residues is the terminal product of the interaction of neutrophils and macrophages with Hb in the hemorrhaged AAA. This oxidized Hb, ferrylHb is taken up b

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12637250 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature