Modulating the sense of agency in functional neurological disorder using real-time fMRI neurofeedback: a proof-of-concept study.

ABSTRACT:

Background

Disrupted sense of agency (SoA), the perceived loss of control over one's actions, is common in functional neurological disorder (FND) and linked to abnormal activation in agency-related networks, particularly the right temporoparietal junction (rTPJ). This proof-of-concept study tested whether fMRI neurofeedback (NF) could enhance SoA in FND by targeting the rTPJ.

Methods

In this single-arm feasibility study, 18 patients with mixed FND symptoms completed three NF trainings during an adaptive visuomotor task, receiving intermittent visual feedback of their rTPJ activity. Pre- and post-training assessments included subjective agency ratings, neuroimaging during a transfer task, and clinical evaluations.

Results

Group-level subjective agency significantly inc

SUBMITTER: Muller E 

PROVIDER: S-EPMC12637265 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature