Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis.

ABSTRACT:

Background

Osteosarcoma is a primary malignant bone tumor that primarily affects adolescents and children, is highly metastatic and invasive, and has a poor survival prognosis. P3H2 is a basement membrane-associated tumor suppressor gene that is down-regulated in some types of tumors. Although some studies have shown that P3H2 has a tumor suppressive effect in some cancers, its role and specific mechanism in osteosarcoma remain unclear. Further analysis of the function and mechanism of the basement membrane-related gene P3H2 in osteosarcoma is expected to provide new insights for early diagnosis and treatment, prognosis evaluation, and targeted drug development.

Methods

In this study, we first investigated the dysregulation of P3H2 in osteosarcoma and pan-cancer by using pub

SUBMITTER: Pan R 

PROVIDER: S-EPMC12637266 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature