Antigen-specific B cell response regulation by IL-10-producing tolerogenic dendritic cells.

ABSTRACT: B cells regulate immune responses via antibody production and antigen (Ag) presentation. Although B cell depletion is used therapeutically, it may be associated with side effects, highlighting the need for alternative B cell-targeted approaches. While tolerogenic dendritic cells (tolDC) are known to modulate T cell responses, their impact on B cells is poorly defined. We show that IL-10-producing tolDC (DC^IL-10) regulate B cell responses through direct and indirect mechanisms. DC^IL-10 enhances T cell-independent human B cell proliferation and differentiation while suppressing Ag-specific memory B cells via T cell inhibition in vitro and dampen Ag-specific IgG production in preclinical humanized and murine models. These findings reveal a dual mechanism by which DC

SUBMITTER: Morali K 

PROVIDER: S-EPMC12637295 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature