Computational modeling reveals biological mechanisms underlying the whisker flick EEG.

ABSTRACT: Whisker flick stimulation is a commonly used protocol to investigate somatosensory processing in rodents. Neural activity evoked by whisker flicks produces a characteristic electroencephalography (EEG) waveform known as a somatosensory evoked potential. In this paper, we use computational modeling to make predictions about the neural populations that contribute to this signal, either through their own membrane currents or the membrane currents they elicit in downstream populations. While the model cannot fully explain the mechanisms of somatosensory evoked potential (SEP) generation, we predict that the initial positive deflection of the EEG waveform is driven largely by direct thalamic inputs to layer 2/3 and layer 5 pyramidal cells, while the negative deflection is driven by a more compl

SUBMITTER: Tharayil J 

PROVIDER: S-EPMC12637391 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature