Axonemal dynein contributions to flagellar beat types and waveforms.

ABSTRACT: Eukaryotic flagella, or motile cilia, are iconic molecular machines whose beating drives cell propulsion and fluid transport across diverse organisms. Beat type and waveform are tailored to function, differing between species and cell types, and individual flagella can switch between beat types. Aberrant beating causes ciliopathies and infertility in humans¹ and prevents unicellular parasite transmission². Eight distinct dynein motor protein complexes bind to axonemal doublet microtubules (DMTs) within flagella and drive beating, yet despite extensive structural analysis^3-5, how this machinery achieves different beat types is unknown. Here, using the flagellate unicellular parasite Leishmania, we show a division of labour where specific dyneins drive

SUBMITTER: Fochler S 

PROVIDER: S-EPMC12637542 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature