Parkinsonian striatal acetylcholine dynamics are refractory to L-DOPA treatment.

ABSTRACT:

Background

Fluctuations in striatal dopamine (DA) are interdependent with fluctuations in acetylcholine (ACh), both of which are thought to be important for motor function and dysfunction in Parkinson's disease (PD).

Objectives

Determine how ACh dynamics are altered by dopamine under normal and parkinsonian conditions following acute and chronic L-DOPA treatment.

Methods

We used fiber photometry to record fluorescent DA and ACh sensors in the dorsomedial striatum (DMS) of normal mice treated with vehicle or amphetamine and in the dorsolateral striatum (DLS) of mice with unilateral substantia nigra (SNc) DA neuron lesions (using 6-OHDA) subjected to an L-DOPA-induced dyskinesia (LID) protocol.

Results

Under normal conditions, ACh exhibited transient increases fo

SUBMITTER: Potjer EV 

PROVIDER: S-EPMC12637546 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature