Nitric oxide tunes secreted metabolite bioactivity.

ABSTRACT: The radical nitric oxide (·NO) is short-lived but has imprinted itself on many aspects of physiology and disease. ·NO's rapid production and consumption, coupled with its intrinsic reactivity, drive its biological importance; thus, defining mechanisms and targets of ·NO reactivity is necessary to assess its fate and impact. Cellular small molecules are a major class of ·NO-reactive targets, possessing a variety of molecular functionalities that can react with ·NO. Yet the capacity for secreted small molecules to react with ·NO, as well as the biological consequences of such reactivity, have received little attention. Here, we explore the reactivity of ·NO with phenazine metabolites, microbially-derived secreted small molecules that possess antibiotic properties and can modulate their micro

SUBMITTER: Lonergan ZR 

PROVIDER: S-EPMC12637565 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature