Seqwin: Ultrafast identification of signature sequences in microbial genomes.

ABSTRACT:

Motivation

Polymerase chain reaction (PCR) enables rapid, cost-effective diagnostics but requires prior identification of genomic regions that allow sensitive and specific identification of target microbial groups, herein referred to as microbial signature sequences. We introduce Seqwin, an open-source framework designed to automate microbial genome signature discovery. Tens of thousands of microbial genomes are now available, limiting the application of existing manual and automated approaches for identifying signatures. Modern approaches that are capable of leveraging all available microbial genomes will ensure sensitive and accurate DNA signatures identification and enable robust pathogen detection for clinical, environmental, and public health applications.

Results

Seqwi

SUBMITTER: Wang MX 

PROVIDER: S-EPMC12637579 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature