Sugar Import Suppresses <i>Klebsiella pneumoniae</i> Mucoidy in cAMP-CRP-dependent Manner.

ABSTRACT: Klebsiella pneumoniae causes over 700,000 global deaths annually and this number continues to rise due to increasing antimicrobial resistance. Hypervirulent K. pneumoniae (hvKp) often causes severe invasive infections in community and hospital settings, typically originating from gut colonization. Capsular polysaccharide (CPS) and the associated features are a key hvKp virulence factor. Altering CPS properties, such as mucoidy, in response to environmental cues enhances K. pneumoniae fitness. Although several physical and nutrient cues influence mucoidy, the molecular mechanisms by which host-relevant signals, such as sugars, regulate this key CPS property remain undefined. Here, we show that sugar import, not catabolism, broadly suppresses hvKp mu

SUBMITTER: Khadka S 

PROVIDER: S-EPMC12637589 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature