Immature olfactory sensory neurons provide complementary input in the healthy olfactory system.

ABSTRACT: Adult neurogenesis of olfactory sensory neurons (OSNs) in the rodent olfactory system provides the unique opportunity to understand how new neurons functionally integrate into existing circuitry and contribute to behaviors. Immature OSNs express odorant receptors (ORs), form dendritic knobs with short cilia, and project their axons into the olfactory bulb (OB) where they form functional synapses. Furthermore, immature OSNs respond selectively to odorants and exhibit graded responses in a higher concentration range than mature OSNs, suggesting that they provide a distinct odor input stream. Finally, in mice that lack mature OSNs, sensory input from immature OSNs is sufficient to mediate odor detection and discrimination behavior. What remains unknown, however, is how these immature OSNs con

SUBMITTER: Gregory JD 

PROVIDER: S-EPMC12637595 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature