HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in <i>C. elegans</i>.

ABSTRACT: Cellular quiescence is a metabolically active, non-proliferative state critical for tissue maintenance and regenerative capacity, with broad implications for aging and age-related diseases. In Caenorhabditis elegans, L1 developmental arrest upon hatching in the absence of food provides a robust in vivo model to study quiescence. Here, we investigate the roles of the transcription factors HLH-30/TFEB and DAF-16/FOXO during L1 arrest. We show that HLH-30 and DAF-16 collaborate to ensure survival under starvation, with reciprocal regulation of their subcellular localization and transcriptional activity. HLH-30 exerts broad transcriptional control during L1 arrest, modulating genes involved in chromosome organization and cell cycle progression. Profiling of chromatin spatial distributio

SUBMITTER: Munoz-Barrera M 

PROVIDER: S-EPMC12637601 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature