3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.

ABSTRACT: 3D bioprinting has revolutionized tissue engineering, enabling intricate, physiologically relevant constructs unattainable with conventional techniques, yet it remains limited in integrating soft and rigid multifunctional components for complex multi-tissue applications. In this study, we introduce a 3D hybrid bioprinting approach implementing the Hybprinter platform, which integrates multiple 3D printing modules under optimized conditions for a continuous bioprinting process with multiple soft and hard biomaterials. This approach demonstrates robust biocompatibility and broad tissue engineering potential for modeling and therapeutic applications. The capacity to fabricate multi-hydrogel hybrid constructs is illustrated by representative examples highlighting vascularization, multifunction

SUBMITTER: Alizadeh HV 

PROVIDER: S-EPMC12637617 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature