Intrinsic ion dynamics underlies the temporal nature of resting-state functional connectivity.

ABSTRACT: The neural mechanisms underlying the emergence of functional connectivity in resting-state fMRI remain poorly understood. Recent studies suggest that resting-state activity consists of brief periods of strong co-fluctuations among brain regions, which reflect overall functional connectivity. Others report a continuum in co-fluctuations over time, with varying degree of correlation to functional connectivity. These findings raise the critical question: what neural processes underlie the temporal structure of resting-state activity? To address this, we used a biophysically realistic whole-brain computational model in which resting-state activity emerged from temporal variations in the ion concentrations of potassium ( K+ ) and sodium ( Na+ ), intracellular chloride ( Cl- ), and the activity

SUBMITTER: Gonzalez OC 

PROVIDER: S-EPMC12637618 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature