A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition.

ABSTRACT: Neuronal excitability relies on the tightly regulated expression and discrete subcellular localization of voltage-gated sodium channels (Na_vs). These large membrane protein complexes control the movement of sodium ions across cell membranes and are responsible for initiating and propagating action potentials. A desire to better understand the role of Na_v subtypes in electrical signal conduction and the relationship between channel dysregulation and specific human pathologies (e.g., epilepsy, musculoskeletal disorders, neuropathic pain) motivates the development of high-precision pharmacological reagents to facilitate Na_v studies. Investigations of Na_v physiology and nerve cell conduction are limited by a lack of available methods with which to mo

SUBMITTER: Park ER 

PROVIDER: S-EPMC12637636 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature