Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels.

ABSTRACT: Anisotropic biological tissues contain hierarchical complexity from the nano to macro length scales. While novel fabrication strategies have advanced the creation of biomimetic architectures, most rely on biologically derived polymers that possess inherent batch-to-batch variability. Here, we fabricate omnidirectional anisotropic nanofibrous hydrogels using synthetic, self-assembling MultiDomain Peptides (MDPs). Using support bath-assisted extrusion 3D printing, MDP hydrogels are created with control over nanometer-scale fibrous alignment, ~150 μm-scale print resolution, and centimeter-scale 3D architecture. Further, scaffold anisotropy is tuned by adjusting the ionic strength of the support bath, allowing fiber alignment to be decoupled from extrusion shear force and the ink used. Applyin

SUBMITTER: Farsheed AC 

PROVIDER: S-EPMC12637642 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature