Sequestration of clock proteins into repressive nuclear condensates orchestrates circadian gene repression.

ABSTRACT: Circadian clocks orchestrate ~24-hour cycles in gene expression, behavior, and physiology across most organisms¹. Our recent study has revealed a striking spatial organization in the nucleus during the repression phase: core clock proteins such as Drosophila PERIOD (PER) are organized into distinct nuclear foci close to the inner nuclear envelope of clock neurons, and clock-regulated genes are similarly positioned in the nucleus². However, the functional relevance of this subnuclear organization is unknown. Here, we investigate how the spatial organization of clock proteins and chromatin regulates circadian gene repression. Given that PER partners with TIMELESS (TIM) to enact transcriptional repression, we first investigated whether TIM is also a component of t

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12637644 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature