Sensory processing reformats odor coding around valence and dynamics.

ABSTRACT: Extracting relevant features of a complex sensory signal typically involves sequential processing through multiple brain regions. However, identifying the logic and mechanisms of these transformations has been difficult, due to the challenges of measuring both activity within and long-range connectivity between multiple neural populations. Here, we investigate the reformatting of odor information across two stages of the Drosophila olfactory system. We measure the odor tuning of 20 types of anatomically-defined third order lateral horn neuron (LHN) and compare to predictions based on the odor tuning of second-order projection neurons (PNs) and PN-LHN connectivity. We find that LHNs reformat PN activity in two distinct ways. First, LHNs selectively discard information about odor iden

SUBMITTER: Lizbinski KM 

PROVIDER: S-EPMC12637714 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature