Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation.

ABSTRACT: How the complex network of intestinal antigen presenting cells (APCs) instructs CD4⁺ T cell responses against the microbiota remains unclear. Here, we use Labeling Immune Partnerships by SorTagging Intercellular Contacts (LIPSTIC) to characterize the APCs that prime CD4⁺ T cells recognizing the commensal bacterium Akkermansia muciniphila. A. muciniphila-specific T cells engaged multiple transcriptionally distinct migratory cDC2 subpopulations, both at homeostasis, when A. muciniphila promotes T_FH differentiation, and during inflammation, when it also drives T_H1 and T_H17 differentiation. The identity of these subpopulations was unchanged by inflammation; however, the distribution of presentation across the subpopula

SUBMITTER: Carroll SL 

PROVIDER: S-EPMC12637724 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature