Smoking Cessation, Weight Change, and Risk of Dementia: A Prospective Cohort Study.

ABSTRACT:

Objectives

To assess the associations of smoking cessation and post-cessation weight gain with the risk of dementia and cognitive trajectories.

Design

Prospective cohort study.

Setting

The U.S. Health and Retirement Study (1995-2020).

Participants

A total of 32,802 dementia-free participants were included, with a mean age of 60.5 years (SD 10.7) and 57.1% female.

Exposure

Smoking status and body weight were collected biennially via structural interviews.

Main outcome measures

Dementia was identified using the Langa-Weir algorithm. Cognitive function was assessed using a 27-unit scale. Cox proportional hazard models estimated hazard ratio (HR) of dementia by smoking cessation status, subsequent weight change, and duration of cessation. Among partic

SUBMITTER: Chen H 

PROVIDER: S-EPMC12637756 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature