Direct intracranial EEG evidence for a local breakdown in normal sleep homeostasis at the human seizure onset zone.

ABSTRACT:

Background

Animal studies have demonstrated that sleep is crucial for physiological synaptic pruning, and that this pruning is primarily regulated at a local, cellular level. We hypothesized that local alterations in sleep homeostatic regulation may constitute an interictal biomarker of the seizure onset zone (SOZ), and that sleep homeostasis abnormalities may also be present in areas beyond the SOZ, proportional to their secondary recruitment during seizures.

Methods

Overnight intracranial EEG (iEEG) recordings were obtained from sixteen well-characterized patients with focal epilepsy. The first and last hour of sleep were analyzed during one seizure-free night with well-organized sleep architecture, selected from each patient. We compared slow-wave activity (SWA; i.e., del

SUBMITTER: Sevak B 

PROVIDER: S-EPMC12637758 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature