Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis.

ABSTRACT: Childhood trauma is a risk factor for bipolar disorder, but the biological mechanisms of this association remain incompletely defined. Gray matter differences observed after trauma exposure overlap with those reported in bipolar disorder, suggesting that the association between childhood trauma and bipolar disorder might be mediated through brain morphology. Our goal was to determine whether cortical thickness, cortical surface or subcortical volume mediate the association between childhood trauma and bipolar disorder. We leveraged a large multi-site dataset from the ENIGMA Bipolar Disorder Working Group, comprising of 1,031 participants with bipolar disorder and 2,221 controls from 19 international cohorts. To identify brain morphology mediators of the association of childhood trauma and

SUBMITTER: Tozzi L 

PROVIDER: S-EPMC12637774 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature