HIV, Nephrotoxic Medications, and Chronic Kidney Disease: Prevalence, Risk Factors, and Mediation Analyses Among People With and Without HIV Enrolled in the Multicenter AIDS Cohort Study (MACS) / Women's Interagency HIV Study (WIHS) Combined Cohort Study.

ABSTRACT:

Background

Chronic kidney disease (CKD) affects over 37 million adults in the United States, and people living with HIV (PLWH) are at greater risk for progression to end-stage kidney disease. Although both conditions are common among PLWH, the potential pathways through which depression and use of medications with nephrotoxic potential may influence CKD development remain underexplored. We evaluated the relationships of depression and nephrotoxic medication use with CKD prevalence among PLWH, and investigated the potential mediating effects of these factors on the pathway to CKD among PLWH.

Methods

We analyzed longitudinal data from the Multicenter AIDS Cohort Study (MACS)/Women's Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS), collected between October 2018 and

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12637789 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature