One step synthesis of ultrafine PHF@AuNPs nanocomposite and its application in NIR triggered photodynamic therapy.

ABSTRACT: Photodynamic therapy (PDT) is a rapid advancing treatment for cancer therapy. The main challenges in PDT include poor absorption in the "tissue optical window" and aggregation tendency of photosensitizers (PS) such as fullerene in aqueous solutions. Herein, we developed a potent nano PS: fullerene hybrid gold nanoparticles (AuNPs) composites which were ultrafine and well-dispersed with a absorption in near infrared (NIR) region. The composites could be facilely prepared by mixing the reducing and capping agent polyhydroxyl fullerene (2 mg/mL) with HAuCl4 (2.425 mM) at equal volume for 2 h. The obtained composites were negatively charged (-26.3 mv) with the particle size of 14.3 nm. A thin layer of fullerene (~1.6 nm) was coated on the AuNPs core. AuNPs in the composites acted as the light

SUBMITTER: Li W 

PROVIDER: S-EPMC12637887 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature