Schistosoma haematobium infection is associated with oncogenic gene expression in Cervical Mucosa, with enhanced effects following treatment: A pilot study.

ABSTRACT:

Background

Schistosoma haematobium is a parasitic worm that infects over 110 million people worldwide, laying eggs that migrate into host urinary and reproductive tracts. While S. haematobium is a known carcinogen in the urinary bladder, its role in cervical cancer remains unclear and molecular effects of parasite eggs in genital tissue are largely unknown. Our objective was to characterize cervical transcriptional profiles in women with or without active S. haematobium infection and after anti-schistosome treatment.

Methods

We collected cervical cytobrush samples from women living in areas of Tanzania endemic for S. haematobium, before and 4-12 months after praziquantel treatment, and extracted RNA for transcriptome analysis. mRNA was isolated using poly(A) selection and se

SUBMITTER: Mertelsmann AM 

PROVIDER: S-EPMC12637897 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature