Anethole inhibits human U87 Glioma cell proliferation by inducing apoptosis via the PI3K/AKT pathway.

ABSTRACT: Glioma is characterized by rapid progression, resistance to conventional therapies, and poor prognosis. Current treatments are often limited by their inability to selectively target tumor cells. Natural compounds, such as anethole, have shown promising anticancer properties in various cancers, but their efficacy in glioblastoma remains unexplored. This study investigates the anticancer activity of anethole in glioma cells, focusing on its influence on cell proliferation, apoptosis, and the PI3K/Akt pathway. Human glioma cell lines (U87-MG and LN-229) and normal human astrocytes (NHA) were treated with anethole. Cell viability was evaluated using the CCK-8 assay, while colony formation and AO/EB staining assays evaluated proliferation and apoptosis, respectively. Cell viability was evaluate

SUBMITTER: Al Awadh AA 

PROVIDER: S-EPMC12637905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature