Adjuvant hyperbaric oxygen therapy reduces the duration of sporotrichosis treatment.

ABSTRACT:

Background

Sporotrichosis is a subcutaneous mycosis caused by Sporothrix spp., typically acquired through traumatic inoculation of fungal spores from soil, plants and infected cat scratches. The disease manifests in various clinical forms, including lymphocutaneous, ocular, bone, and disseminated infections. Standard treatment relies on prolonged administration of antifungals such as itraconazole, terbinafine, and potassium iodide, often requiring months for complete resolution. Moreover, treatment challenges include slow clinical response, recurrence, and potential drug toxicity. Hyperbaric oxygen therapy has been investigated as a potential adjuvant for invasive fungal infections due to its antimicrobial properties, enhanced tissue oxygenation, and immunomodulatory effects, which

SUBMITTER: Duani H 

PROVIDER: S-EPMC12637929 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature