Clinical impact of prophylactic antibiotics in kidney transplantation: A retrospective observational cohort study with historical comparison.

ABSTRACT:

Purpose

Optimal perioperative antibiotic prophylaxis in kidney transplantation remains undefined despite routine antibiotic administration to prevent infections. In this retrospective observational cohort study with historical comparison, we compared the clinical efficacy of 6 days of ampicillin/sulbactam vs. a single dose of cefazolin.

Materials and methods

We retrospectively analyzed 2322 kidney transplantation recipients at a single center, with the evaluation period spanning from 2015 through 2021. Patients were divided into 2 groups based on the perioperative antibiotic regimen received: 971 patients received ampicillin/sulbactam, and 1351 received cefazolin. This study focused on evaluating the impact of these regimens on postoperative infection incidence and the 6-mon

SUBMITTER: Lee SA 

PROVIDER: S-EPMC12637934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature