A mathematical model assuming frequency-dependent cost for analyzing the influence of cell competition on radiation effects.

ABSTRACT: High dose-rate ionizing radiation exposure increases the risk of cancer; however, the health effects of low dose-rate exposure remain controversial. Stem cell competition entails stem cells with lower fitness being eliminated from the stem cell pool when interacting with neighboring stem cells with higher fitness. It is hypothesized that this phenomenon reduces radiation damage under very low dose-rate conditions rather than high dose-rate irradiation conditions. If cell-cell interactions exist, the frequency of cells in a population affects the fitness of cells. However, they have not been adequately considered in discussions of radiation damage accumulation. We developed a mathematical model to analyze the influence of radiation-induced stem cell competition on the accumulation of radiat

SUBMITTER: Uchinomiya K 

PROVIDER: S-EPMC12637972 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature