Performance of novel onchocerciasis rapid diagnostic tests in a field setting in South Sudan.

ABSTRACT:

Introduction

Onchocerciasis is a neglected tropical disease caused by Onchocerca volvulus and is primarily controlled through mass drug administration (MDA) of ivermectin. Current diagnostic tests perform sub-optimally for onchocerciasis elimination programs. According to the WHO, a test needs a sensitivity of ≥60% and a specificity of ≥99.8% for mapping, and a sensitivity of ≥89% and a specificity of ≥99.8% for MDA stopping decisions. We assessed the performance of the commercially available Ov16 SD Bioline rapid diagnostic test (RDT) and three novel RDTs: DDTD biplex type A, type C, and the monoplex type GADx.

Methods

The study included 319 pregnant/post-partum women in Maridi, an onchocerciasis-endemic area in South Sudan. Locally trained healthcare workers conducted RDT

SUBMITTER: Hadermann A 

PROVIDER: S-EPMC12637992 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature