A plasma-based protein signature association with all-cause mortality.

ABSTRACT: Circulating plasma proteins play key roles in measuring and reflecting states of disease and health. Developments in protein metrology allow for over 2,900 proteins to be quantified in a single sample. In major epidemiological studies, this allows for profound insights into protein expression in liquid biopsies, mortality, and morbidity. Here, we have investigated the relationship between peripheral blood protein profiles and non-accident all-cause mortality within 5- and 10-year timeframes, using data on 38,150 participants from the UK Biobank. Adjusting for lifestyle and health covariates, we identified 392 proteins associated with an increase in risk for death within 5-years, and 377 associated with an increase in risk within 10-years. Proteomic signatures of cause-specific mortality (c

SUBMITTER: Koziar N 

PROVIDER: S-EPMC12637995 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature