Dantrolene normalizes heightened Ca²⁺ influx in activated T cells from the familial Alzheimer's disease TgF344-AD rats.

ABSTRACT:

Aim

Dysregulation of the peripheral immune response contributes to Alzheimer's disease pathogenesis. Dantrolene, a negative allosteric modulator of ryanodine receptor types 1 and 3, reduces neurodegeneration in Alzheimer's disease animal models by an unclear mechanism. Given that Alzheimer's disease causative mutations in amyloid precursor and presenilin proteins interfere with intracellular Ca²⁺ signaling in neurons, we tested the hypotheses that these mutations may impair Ca²⁺ signaling in T lymphocytes and that dantrolene can repair this defect.

Methods

We explored cytosolic Ca²⁺ dynamics and effects of dantrolene sodium in resting and activated splenic T cells derived from adult transgenic TgF344-AD rats expressing mutant human "Swedish"

SUBMITTER: Uppal NK 

PROVIDER: S-EPMC12638002 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature