Type III and type VI collagen neoepitopes are associated with disease severity in systemic sclerosis.

ABSTRACT:

Objective

Dysregulated collagen turnover is implicated in systemic sclerosis (SSc) pathogenesis. We evaluated collagen turnover biomarkers in relation to the severity of fibrotic manifestations, key cytokines, and progression in SSc.

Methods

Baseline and 6-month serum samples of early SSc patients in the CONQUER cohort were analyzed for type III (PRO-C3 and C3M) and type VI (PRO-C6 and C6M) collagen turnover biomarkers, as well as C-reactive protein (CRP), interleukin-6 (IL-6), and interferon (IFN)-inducible proteins. The modified Rodnan skin score (mRSS) and forced vital capacity percent predicted (FVC%) served as surrogate markers of disease severity.

Results

222 patients were included. PRO-C3 (p<0.001) and PRO-C6 (p<0.001) concentrations were higher in patients wit

SUBMITTER: Ayla AY 

PROVIDER: S-EPMC12638017 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature