Evidence of populational Burkholderia pseudomallei exposure in Madagascar.

ABSTRACT:

Background

Burkholderia pseudomallei (Bp), the causative agent of melioidosis, poses a significant health risk in endemic regions. This study aimed to characterize six previously identified Bp antigens for exposure monitoring in potential endemic setting of Madagascar and to assess potential exposure and reactivity across Madagascar to inform diagnostic strategies and understand regional exposure patterns.

Methods

Six highly reactive Bp antigens, CPS I, LPS types A and B, HCP1, AhpC, and GroEL, were characterized using the protein BLAST (BLASTp) algorithm against the NCBI non-redundant protein database to evaluate conservation and specificity. Serological reactivity was analyzed in 5,736 serum samples from six regions of Madagascar using Luminex bead-based multiplex assays.

SUBMITTER: Razafimahatratra SL 

PROVIDER: S-EPMC12638028 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature