Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.

ABSTRACT:

Background

The bacterial composition of the microbiome in inflammatory bowel disease (IBD) has been the focus of substantial interest. In contrast, the fungal part of the microbiome, the mycobiome, has only rarely been investigated-although anti-Saccharomyces cerevisiae antibodies, an antibody against fungal mannan, have been known for years as a biomarker for Crohn's disease (CD), but not for ulcerative colitis (UC).

Methods

A systematic review of case-control studies on the human gut mycobiome in IBD was conducted using searches in EMBASE and MEDLINE.

Results

Twenty-seven studies, with a total of 1406 IBD patients and 1060 controls were identified. The differences in alpha diversity varied across studies and were related to geography, whereas differences in beta div

SUBMITTER: Fuchtbauer JD 

PROVIDER: S-EPMC12638052 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature