Return rates for the use of ovarian tissue cryopreserved prior to gonadotoxic treatment as fertility preservation: a systematic review.

ABSTRACT:

Study question

What is the return rate for the use of ovarian tissue cryopreserved for fertility preservation prior to gonadotoxic treatment?

Summary answer

The return rate for the use of ovarian tissue cryopreserved for fertility preservation prior to gonadotoxic treatment is modest, with most studies reporting rates of ≤5%.

What is known already

A considerable number of years have passed since ovarian tissue cryopreservation (OTC) was first implemented for fertility preservation, and many studies now provide long-term follow-up data, including return rates. This allows for a more comprehensive evaluation of OTC as a fertility preservation option and of the characteristics of the population to whom it is offered.

Study design size duration

We searched PubMed,

SUBMITTER: Yde AM 

PROVIDER: S-EPMC12638063 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature