Atrophy patterns of deep gray matter nuclei in Alzheimer's disease and frontotemporal dementia.

ABSTRACT: BackgroundWhile cortical atrophy has been widely studied in dementia, emerging evidence highlights the role of subcortical degeneration, particularly in deep gray matter structures such as the thalamus, claustrum, and basal nuclei, in both Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, disease-specific subcortical patterns remain undercharacterized.ObjectiveTo quantify deep gray matter atrophy across the AD continuum (mild cognitive impairment and AD) and three FTD subtypes (bvFTD, svFTD, PNFA), and to assess longitudinal atrophy, cognitive associations, and diagnostic classification.MethodsWe applied a novel segmentation pipeline (sTHOMAS) to T1-weighted MRI data from 380 participants in the ADNI cohort and 274 participants in the FTLDNI cohort, with longitudinal fol

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC12638095 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature