Altered Neural Activity in Adolescent Major Depressive Disorder With Nonsuicidal Self-Injury: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis.

ABSTRACT:

Background

Resting-state functional magnetic resonance imaging (rs-fMRI) reveals diverse neural activity patterns in adolescent major depressive disorder (MDD) with nonsuicidal self-injury (NSSI; nsMDD). However, the reported results are inconsistent. The aim of this study was to conduct a meta-analysis to identify consistent patterns of brain activity alterations in adolescent nsMDD.

Methods

A systematic search was conducted across PubMed, Web of Science, Embase, Google Scholar, Wanfang, and CNKI for rs-fMRI studies that compared nsMDD patients with healthy controls (HCs), up to June 30, 2025. Significant cluster coordinates were extracted for comprehensive analysis. We utilized regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFFs) analyses. Activa

SUBMITTER: Shu Y 

PROVIDER: S-EPMC12638161 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature