Glucose Uncouples Nitrogen Sensing From Chlorosis via a Photosynthetic Checkpoint in Synechocystis sp. PCC 6803.

ABSTRACT: Cyanobacteria adapt to nitrogen starvation by undergoing chlorosis, a regulated bleaching process that involves the degradation of phycobilisomes, the light-harvesting antennae complexes, and accumulation of glycogen. While this response is well characterized under photoautotrophic conditions, its modulation by external organic carbon sources such as glucose remains poorly characterized. Here, we investigated how glucose affects the response to nitrogen deprivation in the model cyanobacterium Synechocystis sp. PCC 6803. Using an integrative approach combining physiological assays, targeted metabolomics, RNA sequencing, chlorophyll fluorescence and absorbance spectroscopy, we studied the underlying regulatory mechanisms, focusing on photosynthetic electron transport. Glucose supplementation

SUBMITTER: Ortega-Martinez P 

PROVIDER: S-EPMC12638213 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature