Postnatal choline supplementation improves sleep in a rat model of developmental alcohol exposure.

ABSTRACT:

Background

Fetal alcohol spectrum disorders (FASD) is an umbrella term used to describe physical, neuropathological, and behavioral alterations caused by prenatal alcohol exposure. Caretakers often report that children with FASD experience sleep problems. However, interventions to improve sleep have not been well-studied in this population. Interestingly, supplementation with the essential nutrient choline can attenuate many behavioral alterations associated with prenatal alcohol exposure. Moreover, choline is a precursor to acetylcholine, a neurochemical that is also involved in sleep-wake modulation. Using an animal model, this study investigated the effects of developmental alcohol exposure on sleep and examined whether postnatal choline supplementation can modulate sleep altera

SUBMITTER: Hanson JB 

PROVIDER: S-EPMC12638278 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature