Equilibrium state dynamics-based modeling of temporal dose delivery dependencies of FLASH skin sparing.

ABSTRACT:

Background

FLASH radiotherapy shows promise in sparing normal tissues while maintaining tumor control, with the magnitude of its sparing effect being strongly influenced by the temporal dose delivery (TDD) structure of ultra-high dose rate (UHDR) irradiation. Quantitatively describing these dependencies is critical for optimizing UHDR treatments and guiding preclinical and clinical applications.

Purpose

This study introduces perturbed equilibrium state dynamics (ESD) as a minimal phenomenological framework to describe TDD dependencies of FLASH normal tissue sparing.

Methods

ESD-based modeling assumes a transient perturbation of a generic equilibrium state during irradiation, modulating the biological system's instantaneous radiosensitivity. Isoeffective dose ratios (F

SUBMITTER: Bohlen TT 

PROVIDER: S-EPMC12638282 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature