Liver molecular networks associated with drinking behavior in nonhuman primates.

ABSTRACT:

Background

Consumed ethanol is primarily metabolized by the liver, with resulting products of ethanol metabolism, acetaldehyde and salsolinol that influence brain activity and alcohol drinking behavior. Alcohol consumption in humans is highly heritable with numerous associated genetic variants. Functional variants in the ADH and ALDH genes influence liver alcohol metabolism but only account for a small percentage of variance in consumption. We hypothesized that variation in hepatic molecular networks during the induction phase, where animals consume identical amounts of alcohol, predicted variation in drinking behavior during subsequent ad libitum access in nonhuman primates (NHPs).

Methods

We studied male rhesus macaques at baseline and during the uniform consumption phase

SUBMITTER: Cox LA 

PROVIDER: S-EPMC12638284 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature