Genotype-by-sex interaction analyses for alcohol use disorder across biobanks.

ABSTRACT:

Background

Alcohol use and alcohol use disorder (AUD) are significant contributors to morbidity and mortality, with different prevalences between males and females. Despite the established genetic contribution to AUD, sex as a biological variable and the interplay with genetic factors in the disorder remain largely unexplored. This study aimed to address the key question as to how genetic variations interact with biological sex to influence the AUD risk.

Methods

We conducted genome-wide genotype-by-sex (G × S) interaction analyses using multiancestry datasets from the Million Veteran Program (MVP) and UK Biobank (UKB). In total, 1,039,476 participants were analyzed, comprising 150,429 AUD cases and 889,046 controls. AUD cases were defined using ICD-9/10 codes in the MVP and

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12638285 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature